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Diabetes is associated with reduced risk of prostate cancer, but whether the metabolic syndrome is associated with prostate cancer is not established.The authors assessed this association in the Atherosclerosis Risk in Communities (ARIC) Study, comprising 6,429 men in four US communities initially with no history of cancer and aged 45–64 years.

Follow-up for prostate cancer incidence ( = 385 through 2000) was accomplished through cancer registry and hospital linkage.Your access to the NCBI website at gov has been temporarily blocked due to a possible misuse/abuse situation involving your site.This is not an indication of a security issue such as a virus or attack.At baseline, 1,871 men (29.5%) had the metabolic syndrome.After the authors adjusted for other risk factors, men with the metabolic syndrome (≥3 components) were significantly less likely to develop prostate cancer (relative risk = 0.77, 95% confidence interval: 0.60, 0.98) than men without the metabolic syndrome.

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