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Objective: The primary objectives of our study were to test the hypothesis that Se deficiency is associated with genomic hypomethylation of lymphocyte DNA and to determine whether Se levels are associated with blood As (b As) and urinary As (u As) concentrations in adults exposed to As-contaminated groundwater in Bangladesh.

A secondary objective was to explore the relationships between plasma Se and As metabolites.

Se concentrations were inversely associated with total As concentrations (micrograms per liter) in blood (β = –0.04; 95% CI, –0.08 to –0.01) and urine (β = –20.1; 95% CI, –29.3 to –10.9).

Molybdenum is also present in water in varying amounts.

Methylation of inorganic arsenic to produce mono-, di-, or trimethylated products is the central process in the cellular metabolism of arsenic.

Identification of arsenic ( 3 oxidation state) methyltransferase (As3mt) as the enzyme that could catalyze all the steps in the pathway for arsenic methylation suggests that expression of this enzyme could be a useful target for manipulation.

Molybdenum is stored in the body, particularly in the liver, kidneys, glands, and bones.

It is also found in the lungs, spleen, skin, and muscles.




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